Dapoxetine

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Dapoxetine, also known as Priligy, is an example of Selective Serotonin Reuptake Inhibitors (SSRIs). It is usually prescribed for erectile dysfunction, a condition where a man ejaculates too quickly during sexual intercourse. Dapoxetine is presented as round tablets with different colors, depending on the brand name.

Uses of Dapoxetine

This drug is potent for the treatment of premature ejaculation in men aged 18 – 64 who have the following:

  • Poor ejaculation control that is characterized by persistent or recurrent ejaculation with minimal sexual arousal shortly on, before, or after vaginal penetration against the person's wish.
  • Ejaculation under two minutes of vaginal penetration and stimulation known as intravaginal ejaculatory latency time of < 2 mins. 
  • Marked distress due to premature ejaculation.

How Does Dapoxetine Work

Being an SSRI, Dapoxetine works by antagonizing the serotonin transporter. Serotonin is a neurotransmitter that helps in ejaculatory signals. Therefore, the inhibition of neutral serotonin reuptake allows for an increase in serotonin action time on the postsynaptic clefts. Not only does it increase the time it takes to ejaculate but also ensures ejaculation control.

Precautions

It is important that you read these precautions carefully before taking this drug. Also, if you have personal concerns about the safety of this medication, ensure to speak with a health professional. 

 

Do inform your doctor if you have allergies to Dapoxetine or related compounds. Also inform your doctor if you have any history of any of the following:

 

  • Certain types of heart disorder (e.g. heart rhythm disorders or heart failure);
  • Bleeding or blood clotting disorders; 
  • Tendency to faint;
  • Increased ocular pressure (glaucoma);
  • Moderate or severe forms of liver diseases;
  • Kidney disorders;
  • Epilepsy;
  • Mental health problems like mania, depression, or bipolar disorders;
  • Alcoholism;
  • Drug or controlled substance abuse;
  • Treatment with monoamine oxidase inhibitors (MAOIs) within the past two weeks.

Dapoxetine should not be used for children who are less than 18 years of age. It is also not intended for use in women who are pregnant or nursing a baby. 

Because this drug may cause dizziness, drowsiness, or fainting, it is better to avoid operating heavy machines or driving for long distances when on Dapoxetine therapy. 

 

Consuming alcohol while using Dapoxetine can increase dizziness and drowsiness.

Additionally, you should avoid consuming grape juice within 24 hours prior to your use of Dapoxetine. It can increase the concentration of Dapoxetine hydrochloride in your body.

 

You should avoid ingesting this medicine except you have been clinically diagnosed to have erectile dysfunction. 

Dapoxetine Dosage and Administration

Dapoxetine is taken by mouth, with a meal or on an empty stomach. You should swallow the tablets whole with plenty of water to avoid the bitter taste. It is important to consume Dapoxetine only when needed. 

 

The recommended dose is 30 mg (single tablet), 1 – 3 hours before sexual intercourse. Your doctor may have to increase your dose to 60 mg if they observe that the initial dose is insufficient and you are able to tolerate it without experiencing adverse effects like fainting.

 

Do not take this drug everyday or consume more than 30 mg in a 24-hour period as it can increase your chances of developing serious side effects. 

Side Effects of Dapoxetine

The various side effects that have been observed in people using this drug include:

 

  • Headaches;
  • Excessive sweating;
  • Anxiety;
  • Dizziness;
  • Blurred vision;
  • Increase in blood pressure; 
  • Nervousness and confusions; 
  • Decrease in libido;
  • Fast or irregular heartbeats;
  • Abnormal dreams;
  • Ringing sensation the ear;
  • Erection problems;
  • Diarrhea;
  • Nausea and vomiting;
  • Excessive tiredness;
  • Sleepiness;
  • Dry mouth.

Missed Dose and Overdose

Because this drug is taken only when needed, you are less likely to miss a dose or worry about missed doses. However, you should not increase your doses without doctor's approval to avoid overdose and serious side effects. If you suspect an overdose or accidental poisoning, call 911 or the poison control center in your area. 

Interactions 

Dapoxetine interacts with several drugs and four disease conditions. Some of the drugs include:

 

  • Acalabrutinib (taking both Dapoxetine and Acalabrutinib can increase risks of bleeding);
  • Monoamine oxidase inhibitors like Tranylcypromine and Moclobemide;
  • St. John's wort;
  • Tryptophan;
  • Antidepressants (Sertralin, Amitriptyline, Paroxetine, Venlafaxine, Escitalopram, Nortriptyline, Doxepin, Fluvoxamine);
  • Antibiotics like Linezolid, Clarithromycin, Telithromycin, and Erythromycin;
  • Fluconazole;
  • Tramadol;
  • Ketoconazole;
  • Warfarin;
  • Lithium;
  • Ritonavir;
  • Verapamil. 

 

The disease interactions of Dapoxetine are:

  • Glaucoma, characterized by increased fluid pressure in the eye. Dapoxetine should be used with caution in Glaucoma patients to reduce side effects like blurred vision or blindness.
  • Impaired kidney function. Dapoxetine is eliminated from the kidney. It should be used with caution in people with mild to moderate kidney impairment so that it does not accumulate in the blood.
  • Depression
  • Liver dysfunction

Taking Dapoxetine with grape juice can increase the concentration of the drug in your blood longer than needed.

Storage

Dapoxetine should be stored in a cool dry place, out of the reach of children and pets.