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Neurontin is a prescription anti-epileptic medication that is also used as an anticonvulsant. It is also known as Gabapentin, Horizant, or Gralise and belongs to a class of drugs called gamma-aminobutyric acid (GABA) analogs. Neurontin comes as capsules or tablets, having its name and dosage imprinted on it. Also, it is available in liquid forms for pediatric patients.

Uses of Neurontin (Gabapentin)

  • Neurontin is used in the treatment of nerve pains due to herpes viral infection or shingles (herpes zoster), that is, postherpetic neuralgia.
  • It is also used for the prevention/control of partial seizures in adults and children who are at least 3 years of age.
  • Another brand of Gabapentin, known as Horizant, is approved for the treatment of various forms of primary restless leg syndrome.

How Does Neurontin Work?

For seizures to occur or for one to feel pain, there is usually an excitation of nerve cells (neurons) in the brain. Gamma-aminobutyric acid (GABA) helps in reducing the excitability of these neurons by calming them. As a result, their transmission of pain or seizure signals is reduced. Neurontin, being an analog of GABA, exhibits similar biological effects.

Precautions

Patients should adhere to the following instructions before and while consuming Neurontin:

  • Do not use this drug if you are allergic to Neurontin. Also, do not stop using it suddenly even if you start feeling fine.
  • Neurontin is believed to cause life-threatening breathing problems in people who have a pre-existing respiratory disorder.
  • Do well to inform your doctor if you have any history of:
    • Chronic Obstructive Pulmonary Disease (COPD) or another breathing or lung disorder
    • Thoughts of suicide, mood swings, and episodes of depression
    • Drug addiction
    • Kidney impairment
    • Heart disorders
    • Seizures
    • Diabetes
    • Liver diseases
    • For patients with Willis-Ekbom disease or Restless leg syndrome, if you work on the night shift or are a day sleeper
  • It is important to tell your doctor if you are pregnant or planning to get pregnant while taking Neurontin.
  • If you are a breastfeeding mother, your doctor will have to determine how safe it is for you to use this drug while still breastfeeding. Neurontin should only be taken by breastfeeding mothers when the benefits outweigh the risks.
  • Avoid administering Neurontin to children who are less than 3 years of age.

Neurontin Dosing and Administration

You should take this medicine following your physician’s prescription. However, it is important to avoid consuming less or more than necessary. Neurontin is an oral medicine and should be swallowed whole with a glass of water. Also, you can take it with or without a meal.

If you need to break a tablet to get the required dose, do it evenly and take one half while ensuring the remainder is well covered. You should consume any broken tablet as soon as possible, preferably for the next dose. When using the liquid forms, always ensure you measure the volume accurately with the inserted dosing device.

The body absorbs different forms of Gabapentin differently. Hence, avoid switching from one brand or form to another without your doctor's approval. Neurontin is best taken at bedtime to minimize the side effects.

The dose of Neurontin to take is dependent on the severity of the condition as well as weight of the individual. In children, dosage is mainly based on weight. Your doctor may increase the dose as you progress with therapy. Also, people who have kidney or liver impairment may require dosage adjustments as determined by their Doctor.

Dosage for Treatment of Epilepsy in Adults: The usual starting dose for adults is 300 mg once on the first day, 300 mg twice on day two and 300 mg thrice on day three. The maintenance dose for adults is 300-600 mg three times daily. However, the maximum daily dose should not exceed 3600 mg in 3 intervals.

Dosage for Treatment of Epilepsy in Pediatrics: In children 3-12 years of age, the initial dose for epilepsy is 10-15 mg/kg/day in three divided doses. The initial dose for those who are 12-17 years old is 300 mg once on day one, 300 mg twice on day two and 300 mg thrice on day 3. The maintenance dose in children >12 years is 900-1800 mg while the maximum daily dose is 3600 mg in three divided doses.

Dosage for Postherpetic Neuralgia: The initial dose in adults is the same as in epilepsy. However, the maximum daily dose is 1800 mg.

Neurontin Side Effects

The common side effects are:

  • Dizziness
  • Blurred vision
  • Topiramate
  • Ambien
  • Cymbalta
  • Clonazepam

Neurontin interacts with the following diseases:

  • Kidney dysfunction
  • Hemodialysis
  • Suicidal tendency
  • Drug dependency

Missed Dose and Overdose

If you miss a dose, take it as soon as you can remember. But you can skip the missed dose if the time for your next dose is close. Also, if you suspect overdose or poisoning, contact the poison control center immediately.

Storage

Store in a cool dry place, away from children and pets.